Development/Plasticity/Repair NKCC1-Dependent GABAergic Excitation Drives Synaptic Network Maturation during Early Hippocampal Development
نویسندگان
چکیده
Carsten K. Pfeffer,1,2 Valentin Stein,3 Damien J. Keating,2 Hannes Maier,4 Ilka Rinke,3 York Rudhard,2 Moritz Hentschke,5 Gabriele M. Rune,6 Thomas J. Jentsch,1,2 and Christian A. Hübner2,5,7 1Max Delbrück Centrum für Molekulare Medizin (MDC) and Leibniz Institut für Molekulare Pharmakologie (FMP), D-13125 Berlin, Germany, 2Zentrum für Molekulare Neurobiologie Hamburg (ZMNH), Universität Hamburg, D-20251 Hamburg, Germany, 3Max Planck Institut für Neurobiologie, D-82152 Martinsried, Germany, and 4Klinik für Hals-, Nasenund Ohrenheilkunde, 5Institut für Humangenetik, 6Institut für Anatomie, Universitätsklinikum Hamburg-Eppendorf, D-22529 Hamburg, Germany, and 7Institut für Klinische Chemie, Friedrich Schiller Universität Jena, D-07747 Jena, Germany
منابع مشابه
NKCC1-dependent GABAergic excitation drives synaptic network maturation during early hippocampal development.
A high intracellular chloride concentration in immature neurons leads to a depolarizing action of GABA that is thought to shape the developing neuronal network. We show that GABA-triggered depolarization and Ca2+ transients were attenuated in mice deficient for the Na-K-2Cl cotransporter NKCC1. Correlated Ca2+ transients and giant depolarizing potentials (GDPs) were drastically reduced and the ...
متن کاملNMDA-dependent switch of proBDNF actions on developing GABAergic synapses.
The brain-derived neurotrophic factor (BDNF) has emerged as an important messenger for activity-dependent development of neuronal network. Recent findings have suggested that a significant proportion of BDNF can be secreted as a precursor (proBDNF) and cleaved by extracellular proteases to yield the mature form. While the actions of proBDNF on maturation and plasticity of excitatory synapses ha...
متن کاملEarly enriched environment promotes neonatal GABAergic neurotransmission and accelerates synapse maturation.
Environmental stimulation is critical for brain development. Here, we report that natural stimulation through enriched environment (EE) rearing during the first 2 weeks of mouse postnatal development promotes GABAergic neurotransmission and accelerates maturation of GABAergic and glutamatergic synapses. Using whole-cell recordings from CA1 pyramidal neurons in acute hippocampal slices, we found...
متن کاملDevelopmental Effects of Melatonin on Synaptic Plasticity of Hippocampal CA1 Neurons in Visual Deprived Rats
Background & Aims: Change in visual experience impairs circadian rhythms. In this study, The effects of visual deprivation during critical period of brain development and melatonin intake on synaptic plasticity of hippocampal CA1 neurons were evaluated. Methods: This experimental study was done on male rats kept in standard 12 hour light/dark condition (L...
متن کاملDepolarizing GABAergic conductances regulate the balance of excitation to inhibition in the developing retinotectal circuit in vivo.
Neurotransmission during development regulates synaptic maturation in neural circuits, but the contribution of different neurotransmitter systems is unclear. We investigated the role of GABAA receptor-mediated Cl- conductances in the development of synaptic responses in the Xenopus visual system. Intracellular Cl- concentration ([Cl-]i) was found to be high in immature tectal neurons and then f...
متن کامل